This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all ...
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This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritativeand practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.
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Add this copy of Cytochrome P450: In Vitro Methods and Protocols to cart. $122.11, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2022 by Springer-Verlag New York Inc..
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New. Print on demand Contains: Illustrations, black & white, Illustrations, color. Methods in Pharmacology and Toxicology . XI, 379 p. 94 illus., 40 illus. in color. Intended for professional and scholarly audience.
Add this copy of Cytochrome P450: in Vitro Methods and Protocols to cart. $153.94, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Santa Clarita, CA, UNITED STATES, published 2022 by Humana.
Add this copy of Cytochrome P450: In Vitro Methods and Protocols to cart. $159.66, new condition, Sold by Ria Christie Books rated 4.0 out of 5 stars, ships from Uxbridge, MIDDLESEX, UNITED KINGDOM, published 2022 by Springer-Verlag New York Inc..
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Seller's Description:
New. Contains: Illustrations, black & white, Illustrations, color. Methods in Pharmacology and Toxicology . XI, 379 p. 94 illus., 40 illus. in color. Intended for professional and scholarly audience.
Add this copy of Cytochrome P450: In Vitro Methods and Protocols to cart. $187.87, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2021 by Humana.
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New. Print on demand Sewn binding. Cloth over boards. 379 p. Contains: Unspecified, Illustrations, black & white, Illustrations, color, Tables, color. Methods in Pharmacology and Toxicology.
Add this copy of Cytochrome P450: in Vitro Methods and Protocols to cart. $200.81, new condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Santa Clarita, CA, UNITED STATES, published 2022 by Humana.
Add this copy of Cytochrome P450: In Vitro Methods and Protocols to cart. $226.26, new condition, Sold by Ria Christie Books rated 4.0 out of 5 stars, ships from Uxbridge, MIDDLESEX, UNITED KINGDOM, published 2021 by Humana.
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
New. Sewn binding. Cloth over boards. 379 p. Contains: Unspecified, Illustrations, black & white, Illustrations, color, Tables, color. Methods in Pharmacology and Toxicology.
