Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of ...
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Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in thesurface science, pharmaceutical, and medicinal chemistry areas.
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Add this copy of Protein Instability at Interfaces During Drug Product to cart. $103.32, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2022 by Springer Nature Switzerland AG.
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New. Print on demand Contains: Illustrations, black & white, Illustrations, color. AAPS Advances in the Pharmaceutical Sciences Series . VIII, 338 p. 58 illus., 41 illus. in color. Intended for professional and scholarly audience.
Add this copy of Protein Instability at Interfaces During Drug Product to cart. $129.05, new condition, Sold by Just one more Chapter rated 3.0 out of 5 stars, ships from Miramar, FL, UNITED STATES, published 2022 by Springer.
Add this copy of Protein Instability at Interfaces During Drug Product to cart. $132.45, new condition, Sold by Ria Christie Books rated 4.0 out of 5 stars, ships from Uxbridge, MIDDLESEX, UNITED KINGDOM, published 2022 by Springer Nature Switzerland AG.
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New. Contains: Illustrations, black & white, Illustrations, color. AAPS Advances in the Pharmaceutical Sciences Series . VIII, 338 p. 58 illus., 41 illus. in color. Intended for professional and scholarly audience.
Add this copy of Protein Instability at Interfaces During Drug Product to cart. $150.29, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2021 by Springer.
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New. Print on demand Sewn binding. Cloth over boards. 338 p. Contains: Unspecified, Illustrations, black & white, Illustrations, color, Tables, color. Aaps Advances in the Pharmaceutical Sciences, 43.
