V M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical ...
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V M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu- ronal transmission and, more broadly, of behavior. The first suggestion that transmethylation processes might be involved in the origina- tion of certain mental diseases came from Harley-Mason (1952), who noticed that many of the hallucinogenic substances known at that time contained methyl radicals, and par- ticularly that mescaline represented the product of O-methylation of dopamine in posi- tions 3, 4, and 5. This hypothesis was put forward when the O-methylation of catechol- amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla- tion might follow a "deviant" metabolie pathway, and that the accumulation of abnor- mal methylated metabolites endowed with hallucinogenic properties might be responsi- ble for the implementation of some mental diseases, notably schizophrenia. He also called attention to a substance, 3,4-dimethoxyphenylethylamine (3,4-DMPEA) as a possible psychotogenic moleeule, on the strength of its capacity for producing cata- tonia in experimental animals.
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Add this copy of Transmethylations and the Central Nervous System to cart. $51.65, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2014 by Springer-Verlag Berlin and Heidelberg GmbH & Co. K.
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2014, Springer-Verlag Berlin and Heidelberg GmbH & Co. K
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Springer-Verlag Berlin and Heidelberg GmbH & Co. K
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2014
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New. Print on demand Contains: Illustrations, black & white. Monographien aus dem Gesamtgebiete der Psychiatrie . VI, 188 p. 18 illus. Intended for professional and scholarly audience.
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Edition:
2014, Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Publisher:
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Published:
2014
Language:
English
Alibris ID:
18321140377
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New. Contains: Illustrations, black & white. Monographien aus dem Gesamtgebiete der Psychiatrie . VI, 188 p. 18 illus. Intended for professional and scholarly audience.
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Edition:
2014, Springer-Verlag Berlin and Heidelberg GmbH & Co. K
