Cells face and react to their environment to ensure viability or to fulfil specialized tasks. Therefore, they evolved highly coordinated interconnected signalling networks to sense extra- or intra-cellular stimuli and generate diverse changes in the cellular physiology ranging from transcription modification to the activation or repression of various protein functions. These signalling networks often include molecules that can be covalently attached to other molecules such as proteins, nucleic acids, or lipids to alter ...
Read More
Cells face and react to their environment to ensure viability or to fulfil specialized tasks. Therefore, they evolved highly coordinated interconnected signalling networks to sense extra- or intra-cellular stimuli and generate diverse changes in the cellular physiology ranging from transcription modification to the activation or repression of various protein functions. These signalling networks often include molecules that can be covalently attached to other molecules such as proteins, nucleic acids, or lipids to alter their affinities towards binding partners. Alternatively, such attachments may modulate the enzymatic activity of the modified proteins or affect their cellular localization. These attachments, commonly referred as post-translational modifications (PTMs), generate quicker responses and initiate instant downstream signalling compared to the transcription/translation machinery (Walsh and Jefferis, 2006). PTMs usually involve reversible covalent attachment of molecules such as phosphate, methyl or acetyl groups to proteins (Cohen, 2001; Walsh and Jefferis, 2006; Yang and Seto, 2008). Additionally, proteins in eukaryotes may get modified by covalent attachment of small proteins like ubiquitin (Ub), SUMO (Small ubiquitin-related modifier), or Nedd8. These modifications are often classified as UbLyations and the modifiers as UbLs (Ubiquitin Like proteins) as Ub was the first one to be identified and characterized amongst these. In fact, the attachment of Ub has been established to play many cellular roles as it can alter the function as well as the fate of the substrate proteins.
Read Less
Add this copy of A Biomolecular And Conformational Investigation Of to cart. $28.34, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2025 by Independent Publisher.
Add this copy of A Biomolecular and Conformational Investigation of to cart. $36.17, new condition, Sold by Just one more Chapter rated 3.0 out of 5 stars, ships from Miramar, FL, UNITED STATES, published 2025 by Independent Publisher.
Add this copy of A Biomolecular And Conformational Investigation Of to cart. $38.27, like new condition, Sold by GreatBookPrices rated 4.0 out of 5 stars, ships from Columbia, MD, UNITED STATES, published 2025 by Independent Publisher.
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
Fine. Trade paperback (US). Glued binding. 152 p. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
Add this copy of A Biomolecular And Conformational Investigation Of to cart. $38.66, new condition, Sold by GreatBookPrices rated 4.0 out of 5 stars, ships from Columbia, MD, UNITED STATES, published 2025 by Independent Publisher.
Choose your shipping method in Checkout. Costs may vary based on destination.
Seller's Description:
New. Trade paperback (US). Glued binding. 152 p. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
